string reportFile = "AppReport.rpt";
    var rep = new ReportDocument();
    rep.Load(reportFile);
    rep.Database.Tables[0].Location = @"c:\temp\run-rime-access.mdb";
    crystRep.ReportSource = rep;

Exception thrown: 'System.Runtime.InteropServices.COMException' in CrystalDecisions.CrystalReports.Engine.dll
An unhandled exception of type 'System.Runtime.InteropServices.COMException' occurred in CrystalDecisions.CrystalReports.Engine.dll
Error in File AppReport 11476_6424_{59713F00-ED10-4E5B-928E-1D8AC1A7832B}.rpt:
Failed to load database information.

Here is what you need to do make all this work.

1. Install CR for visual studio on your development machine.  It's free.  It's the same version for 32 and 64.
2. Install CR 64 bit run time on the development machine.  It is available for free at SAP site. You can install 32 bit run time at the same time.
3. Install 64 bit ACE Driver on your development machine.  You cannot install 64 bit driver at the same time.  If you have 64 bit office installed on your machine, the installer will not even let you install 32 bit ACE driver.
4. Here comes the hard part.  You have to design you report using a 32 bit data source.  As you can see if you do not have 32 bit ACE driver installed on your machine, you can not create a DSN for it.  Crystal Reports does offer support for accdb natively.  I overcame this issue by using a mdb version of the same access database.  Look at the screenshot below.  You can see that I have a dsn ash-lab-64bit, which uses 64 bit ACE driver.  However in Crystal Reports designer I only see ash-lab-32bit dsn, which uses natively supported mdb (DAO) driver in Crystal Reports.

C# Code to make it all work in 64 bit run time environment:

1. Get rid of  uselegacyv2runtimeactivationpolicy attribute from app.config.
   
2. Use the following code if you still like DSN based connections.  Keep in mind that every client will need this connection on his/her machine.
   
   

    string reportFile = "Example3.rpt";
    var rep = new ReportDocument();
    rep.Load(reportFile);
    ConnectionInfo tConnInfo = new ConnectionInfo();
    tConnInfo.DatabaseName = @"c:\temp\__run-time.accdb";
    tConnInfo.ServerName = "ash-lab-64bit";
    tConnInfo.Password = "";
    foreach (CrystalDecisions.CrystalReports.Engine.Table crTable in rep.Database.Tables)
    {
     crTable.LogOnInfo.ConnectionInfo = tConnInfo;
     crTable.ApplyLogOnInfo(crTable.LogOnInfo);
    }
    crystRep.ReportSource = rep;
   
   

3. Use the following if you like DSN less connection.  This is what I prefer.
   
   

    string reportFile = "Example3.rpt";
    var rep = new ReportDocument();
    rep.Load(reportFile);
    rep.DataSourceConnections[0].SetConnection(@"DRIVER=Microsoft Access Driver (*.mdb, *.accdb);UID=admin;UserCommitSync=Yes;Threads=3;SafeTransactions=0;PageTimeout=5;MaxScanRows=8;MaxBufferSize=2048;FIL=MS Access;DriverId=25;DefaultDir=C:\temp;DBQ=C:\temp\__run-time.accdb","",false);
    crystRep.ReportSource = rep;
   
   

4. Compile your code with "ANY CPU" or 64 bit setting.

Software do you need to make it work on the client machine: